Publications
Prober lab publications in Pubmed
2023
The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation
Ida L. Barlow, Eirinn Mackay, Emily Wheater, Aimee Goel, Sumi Lim, Steve Zimmerman, Ian Woods, David A. Prober and Jason Rihel
Elife 12, RP87521 (2023). doi.org/10.7554/eLife.87521.2
2022
Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons
Mahendra Wagle, Mahdi Zarei, Matthew Lovett-Barron, Kristina Tyler Poston, Jin Xu, Vince Ramey, Katherine S Pollard, David A Prober, Jay Schulkin, Karl Deisseroth and Su Guo
Molecular Psychiatry 27, 3777-3793 (2022). doi: 10.1038/s41380-022-01567-x
Molecular Psychiatry 27, 3794 (2022). doi: 10.1038/s41380-022-01647-y (Publisher correction)
Validation of candidate sleep disorder risk genes using zebrafish
Steven Tran and David A. Prober
Frontiers in Molecular Neuroscience 15:873520 (2022). doi: 10.3389/fnmol.2022.873520
Large-scale analysis of sleep in zebrafish
Daniel A. Lee, Grigorios Oikonomou and David A. Prober
Bio-protocol 12:e4313 (2022). doi: 10.21769/BioProtoc.4313
2020
Neuropeptide VF neurons promote sleep via the serotonergic raphe
Daniel A. Lee, Grigorios Oikonomou, Tasha Cammidge, Andrey Andreev, Young Hong, Hannah Hurley and David A. Prober
Elife 9, e54491 (2020). doi: 10.7554/eLife.54491
Evolutionarily conserved regulation of sleep by the protein translational regulator PERK
Sarah Ly, Daniel A. Lee, Ewa Strus, David A. Prober and Nirinjini Naidoo
Current Biology 30, 1639-1648 (2020). doi: 10.1016/j.cub.2020.02.030
Macropinocytosis-mediated membrane recycling drives neural crest migration by delivering F-actin to the lamellipodium
Yuwei Li, Walter G. Gonzalez, Andrey Andreev, Weiyi Tang, Shashank Gandhi, Alexandre Cunha, David Prober, Carlos Lois and Marianne E. Bronner
PNAS 117, 27400-27411 (2020). doi: 10.1073/pnas.2007229117
Prokineticin receptor 2 affects GnRH3 neuron ontogeny but not fertility in zebrafish
Ivan Bassi, Francesca Luzzani, Federica Marelli, Valeria Vezzoli, Ludovica Cotellessa, David A. Prober, Luca Persani, Yoav Gothilf and Marco Bonomi
Scientific Reports 10, 7632 (2020). doi: 10.1038/s41598-020-64077-2
Scientific Reports 15, 8352 (2020). doi: 10.1038/s41598-020-65551-7 (Publisher correction)
Attenuating the epidermal growth factor receptor-extracellular signal-regulated kinase-sex-determining region Y-box 9 axis promotes liver progenitor cell-mediated liver regeneration in zebrafish
Juhoon So, Minwook Kim, Seung-Hoon Lee, Sungjin Ko, Daniel A. Lee, Hyewon Park, Mizuki Azuma, Michael J. Parsons, David Prober and Donghun Shin
Hepatology 73, 1494-1508 (2020). doi: 10.1002/hep.31437
2019
Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signaling
Daniel A. Lee, Justin Liu, Young Hong, Jacqueline M. Lane, Andrew J. Hill, Sarah L. Hou, Heming Wang, Grigorios Oikonomou, Uyen Pham, Jae Engle, Richa Saxena and David A. Prober
Science Advances 5, eaax4249 (2019). doi: 10.1126/sciadv.aax4249
Caltech press release
Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen
Eric A. Mosser, Cindy N. Chiu, T. Katherine Tamai, Tsuyoshi Hirota, Suna Li, May Hui, Amy Wang, Chanpreet Singh, Andrew Giovanni, Steve A. Kay and David A. Prober
Scientific Reports 9, 12405 (2019). doi: 10.1038/s41598-019-48914-7
Inherited and de novo genetic risk for autism impacts shared networks
Elizabeth K. Ruzzo, Laura Pérez-Cano, Jae-Yoon Jung, Lee-Kai Wang, Dorna Kashef-Haghighi, Chris Hartl, Chanpreet Singh, Jin Xu, Jackson N. Hoekstra, Olivia Leventhal, Virpi M. Leppä, Michael J. Gandal, Kelley Paskov, Nate Stockham, Damon Polioudakis, Jennifer K. Lowe, David A. Prober, Daniel H. Geschwind and Dennis P. Wall
Cell 178, 850-866 (2019). doi: 10.1016/j.cell.2019.07.015
The serotonergic raphe promote sleep in zebrafish and mice
Grigorios Oikonomou, Michael Altermatt, Rong-wei Zhang, Gerard M. Coughlin, Christin Montz, Viviana Gradinaru and David A. Prober
Neuron 103 (2019). doi: 10.1016/j.neuron.2019.05.038
Caltech press release | Neuron video abstract
Muller glial cells participate in retinal waves via glutamate transporters and AMPA receptors
Rong-wei Zhang, Wen-jie Du, David A. Prober and Jiu-lin Du
Cell Reports 27, 2871-2880 (2019). doi: 10.1016/j.celrep.2019.05.011
The neuromodulator adenosine regulates oligodendrocyte migration at motor exit point transition zones
Laura Fontenas, Taylor G. Welsh, Melanie Piller, Patricia Coughenour, Avni V. Gandhi, David A. Prober and Sarah Kucenas
Cell Reports 27, 115-128 (2019). doi: 10.1016/j.celrep.2019.03.013
Linking immunity and sickness-induced sleep
Grigorios Oikonomou and David A. Prober
Science 363, 455-456 (2019). doi: 10.1126/science.aaw2113
Reprint
2018
Discovery of hypocretin/orexin ushers in a new era of sleep research
David A. Prober
Trends in Neuroscience 41, 70-72 (2018). doi: 10.1016/j.tins.2017.11.007.
Hypocretin underlies the evolution of sleep loss in the Mexican cavefish
James B. Jaggard, Bethany A. Stahl, Evan Lloyd, David A. Prober, Eric R. Duboue and Alex C. Keene
Elife 7 (2018). doi: 10.7554/eLife.32637.
The Scientist | Nature
2017
Neuropeptide Y regulates sleep by modulating noradrenergic signaling
Chanpreet Singh, Jason Rihel and David A. Prober
Current Biology 27, 3796-3811 (2017). doi: 10.1016/j.cub.2017.11.018.
Caltech press release
Genetic and neuronal regulation of sleep by neuropeptide VF
Daniel A. Lee, Andrey Andreev, Thai V. Truong, Audrey Chen, Andrew J. Hill, Grigorios Oikonomou, Uyen Pham, Young K. Hong, Steven Tran, Laura Glass, Viveca Sapin, Jae Engle, Scott E. Fraser and David A. Prober
Elife 6 (2017). doi: 10.7554/eLife.25727.
Caltech press release
The Jellyfish Cassiopea exhibits a sleep-like state
Ravid D. Nath, Claire N. Bedbrook, Michael J. Abrams, Ty Basinger, Justin S. Bois, David A. Prober, Paul W. Sternberg, Viviana Gradinaru and Lea Goentoro
Current Biology 27, 2984-2990 (2017). doi: 10.1016/j.cub.2017.08.024
Caltech press release | Caltech video | Current Biology Dispatch | Nature | Science | New York Times | Washington Post | Newsweek
Light-dependent regulation of sleep and wake states by prokineticin 2 in zebrafish
Shijia Chen, Sabine Reichert, Chanpreet Singh, Grigorios Oikonomou, Jason Rihel and David A. Prober
Neuron 95, 153-168 (2017). doi: 10.1016/j.neuron.2017.06.001
Caltech press release
Attacking sleep from a new angle: contributions from zebrafish
Grigorios Oikonomou and David A. Prober
Current Opinion in Neurobiology 44, 80-88 (2017). doi: 10.1016/j.conb.2017.03.009
Genetic analysis of histamine signaling in larval zebrafish sleep
Audrey Chen, Chanpreet Singh, Grigorios Oikonomou and David A. Prober
eNeuro 4(1) (2017). doi: 10.1523/ENEURO.0286-16.2017
2016
Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway
Paula Suarez-Bregua, Eva Torres-Nunez, Ankur Saxena, Pedro Guerreiro, Ingo Braasch, David A. Prober, Paloma Moran, Jose Miguel Cerda-Reverter, Shao Jun Du, Fatima Adrio, Deborah M. Power, Adelino V.M. Canario, John H. Postlethwait, Marianne E. Bronner, Cristian Canestro and Josep Rotllant
FASEB Journal 31, 569-583 (2016). doi: 10.1096/fj.201600815R
Mapping a multiplexed zoo of mRNA expression
Harry M.T. Choi, Colby R. Calvert, Naeem Husain, David Huss, Julius C. Barsi, Benjamin E. Deverman, Ryan C. Hunter, Mihoko Kato, S. Melanie Lee, Anna C.T. Abelin, Adam Z. Rosenthal, Omar S. Akbari, Yuwei Li, Bruce A. Hay, Paul W. Sternberg, Paul H. Patterson, Eric H. Davidson, Sarkis K. Mazmanian, David A. Prober, Mat van de Rijn, Jared R. Leadbetter, Dianne K. Newman, Carol Readhead, Marianne E. Bronner, Barbara Wold, Rusty Lansford, Tatjana Sauka-Spengler, Scott E. Fraser and Niles A. Pierce
Development 143, 3632-3637 (2016). doi: 10.1242/dev.14037
Morphological and physiological interactions between GnRH3 and hypocretin/orexin neuronal systems in zebrafish (Danio rerio)
Yali Zhao, Chanpreet Singh, David A. Prober and Nancy L. Wayne
Endocrinology 157, 4012-4020 (2016). doi: 10.1210/en.2016-1381
A zebrafish genetic screen identifies neuromedin U as a regulator of sleep/wake states
Cindy N. Chiu*, Jason Rihel*, Daniel A. Lee, Chanpreet Singh, Eric A. Mosser, Shijia Chen, Viveca Sapin, Uyen Pham, Jae Engle, Brett J. Niles, Christin J. Montz, Sridhara Chakravarthy, Steven Zimmerman, Kourosh Salehi-Ashtiani, Marc Vidal, Alexander F. Schier and David A. Prober
Neuron 89, 842-856 (2016). doi: 10.1016/j.neuron.2016.01.007. * equal contribution
Caltech press release | Neuron press release | Neuron video abstract | Cell press podcast | BBC World Service interview
QRFP and its receptors regulate locomotor activity and sleep in zebrafish
Audrey Chen*, Cindy N. Chiu*, Eric A. Mosser, Sohini Khan, Rory Spence and David A. Prober
Journal of Neuroscience 36, 1823-1840 (2016). doi: 10.1523/jneurosci.2579-15.2016. * equal contribution
Editor highlight | Cover video | Neuronline Summary
TRP channel mediated neuronal activation and ablation in freely behaving zebrafish
Shijia Chen*, Cindy N. Chiu*, Kimberley L. McArthur, Joseph R. Fetcho and David A. Prober
Nature Methods 13, 147-150 (2016). doi: 10.1038/nmeth.3691. * equal contribution
2015
Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish
Chanpreet Singh*, Grigorios Oikonomou* and David A. Prober
Elife 4 (2015). doi: 10.7554/eLife.07000. * equal contribution
Melatonin is required for the circadian regulation of sleep
Avni V. Gandhi, Eric A. Mosser, Grigorios Oikonomou and David A. Prober
Neuron 85, 1193-1199 (2015). doi: 10.1016/j.neuron.2015.02.016
Caltech press release | Caltech video
Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9
Justin Liu, Florian T. Merkle, Avni V. Gandhi, James A. Gagnon, Ian G. Woods, Cindy N. Chiu, Tomomi Shimogori, Alexander F. Schier and David A. Prober
Development 142, 1113-1124 (2015). doi: 10.1242/dev.117424
2013
Regulation of zebrafish sleep and arousal states: current and prospective approaches
Cindy N. Chiu and David A. Prober
Frontiers in Neural Circuits 7:58 (2013). doi: 10.3389/fncir.2013.00058
A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly
Shijia Chen*, Grigorios Oikonomou*, Cindy N. Chiu, Brett J. Niles, Justin Liu, Daniel A. Lee, Igor Antoshechkin and David A. Prober
Nucleic Acids Research 41, 2769-2778 (2013). doi: 10.1093/nar/gks1356. * equal contribution
2010
Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
Jason Rihel*, David A. Prober*, Anthony Arvanites, Kelvin Lam, Steven Zimmerman, Sumin Jang, Stephen J. Haggarty, David Kokel, Lee L. Rubin, Randall T. Peterson and Alexander F. Schier
Science 327, 348-351 (2010). doi: 10.1126/science.1183090. * equal contribution
Harvard Gazette | MIT Tech Review
Monitoring neural activity with bioluminescence during natural behavior
Eva A Naumann*, Adam R. Kampff *, David A Prober, Alexander F. Schier and Florian Engert
Nature Neuroscience 13, 513-520 (2010). doi: 10.1038/nn.2518. * equal contribution
Monitoring sleep and arousal in zebrafish
Jason Rihel, David A. Prober and Alexander F. Schier
Methods in Cell Biology 100, 281-294 (2010). doi: 10.1016/B978-0-12-384892-5.00011-6
2008
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function
David A. Prober, Steven Zimmerman, Benjamin R. Myers, Brian M. McDermott Jr, Seok-Hyung Kim, Sophie Caron, Jason Rihel, Lilianna Solnica-Krezel, David Julius, A.J. Hudspeth and Alexander F. Schier
Journal of Neuroscience 28, 10102-10110 (2008). doi: 10.1523/jneurosci.2740-08.2008
2006
Hypocretin/Orexin overexpression induces an insomnia-like phenotype in zebrafish
David A. Prober, Jason Rihel, Anthony A. Onah, Rou-Jia Sung and Alexander F. Schier
Journal of Neuroscience 25(51):134000-13410 (2006).
Editor highlight
Earlier publications
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
David A. Prober and Bruce A. Edgar
Genes and Development 16, 2286-2299 (2002)
Growth regulation by oncogenes - new insights from model organisms
David A. Prober and Bruce A. Edgar
Current Opinion in Genetics and Development 11, 19-26 (2001)
Ras1 promotes cellular growth in the Drosophila wing
David A. Prober and Bruce A. Edgar
Cell 100, 435-446 (2000)
Drosophila myc regulates cellular growth during development
Laura A. Johnston, David A. Prober, Bruce A. Edgar, Robert N. Eisenman and Peter Gallant
Cell 98, 779-790 (1999)
pp60(c-src) is required for cell locomotion regulated by the hyaluronan receptor RHAMM
Christine L. Hall, Laurie A. Lange, David A. Prober, Shiwen Zhang and Eva A. Turley
Oncogene 13, 2213-2224 (1996)