We are interested in genetic and neural mechanisms that regulate sleep.
We use zebrafish to identify genes, neurons and small molecules that regulate sleep. We also exploit the transparency of zebrafish larvae to monitor and manipulate neural circuits that regulate sleep and wakefulness.
April 29, 2016 - Read David's Rita Allen Foundation Scholar profile.
February 19, 2016 - Listen to David discuss the sleep screen paper on the BBC World Service.
February 17, 2016 - Our paper describing the first large-scale screen for genes that affect vertebrate sleep is online at Neuron. See also the Video Abstract, Neuron press release and Cell Press podcast.
February 1, 2016 - Our paper showing that TRP channels can be used to non-invasively stimulate and ablate zebrafish neurons while monitoring 96 freely-behaving larvae is online at Nature Methods.
September 1, 2015 - Our paper demonstrating non-invasive optogenetics while monitoring 96 freely-behaving larvae is online at eLife.
March 15, 2015 - Our paper showing that the transcription factor Lhx9 regulates the specification of Hcrt neurons in zebrafish and mice is online at Development.