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Sleep is among the most enduring mysteries in biology. Despite the fact that we devote a third of our lives to sleep, the pervasiveness of sleep disorders and the evolutionary conservation of sleep-like states, mechanisms that underlie this behavioral state remain poorly understood. We are taking a new approach to this old problem by using zebrafish to identify genetic and neuronal mechanisms that regulate sleep and wakefulness.

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News

September 21, 2017 - Read a new study from three talented Caltech students describing a sleep-like state in the jellyfish Cassiopea, demonstrating that sleep arose in animals before the evolution of a central nervous system, and pushing back the emergence of sleep by at least 600 million years. See also the Caltech video.

September 18, 2017 - Congratulations to Andrew on being awarded an NIH Predoctoral fellowship!

June 22, 2017 - Our paper showing that prokineticin 2 regulates the direct effects of light and dark on sleep is online at Neuron! See also the Caltech press release.

March 1, 2017 - Congratulations to David on his promotion to Professor!

February 22, 2017 - Watch David's Watson Lecture: Using fish to understand how and why we sleep.

September 15, 2016 - Congratulations to Dan on being awarded a K99 Pathway to Independence grant from the NIH and a Young Investigator award from the Brain and Behavioral Research Foundation!

September 1, 2016 - Congratulations to Steve on being awarded an NSERC postdoctoral fellowship!

August 1, 2016 - Congratulations to Uli on being awarded a German Research Foundation postdoctoral fellowship!

April 29, 2016 - Read David's Rita Allen Foundation Scholar profile.

February 19, 2016 - Listen to David discuss the sleep screen paper on the BBC World Service.

February 17, 2016 - Our paper describing the first large-scale screen for genes that affect vertebrate sleep is online at Neuron! See also the Video Abstract, Neuron press release and Cell Press podcast.

February 10, 2016 - Our paper showing that QRFP and its receptors regulate locomotor activity and sleep is online at the Journal of Neuroscience! See also the Editor Highlight.

February 1, 2016 - Our paper showing that TRP channels can be used to non-invasively stimulate and ablate zebrafish neurons while monitoring 96 freely-behaving larvae is online at Nature Methods!

September 1, 2015 - Our paper demonstrating non-invasive optogenetics while monitoring 96 freely-behaving larvae is online at eLife!

March 18, 2015 - Our paper demonstrating that melatonin is required for the circadian regulation of sleep is online at Neuron! See also the Caltech Video.

March 15, 2015 - Our paper showing that the transcription factor Lhx9 regulates the specification of Hcrt neurons in zebrafish and mice is online at Development!