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Publications

Prober lab publications in Pubmed

2019

Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen
Eric A. Mosser, Cindy N. Chiu, T. Katherine Tamai, Tsuyoshi Hirota, Suna Li, May Hui, Amy Wang, Chanpreet Singh, Andrew Giovanni, Steve A. Kay and David A. Prober
Scientific Reports 9, 12405 (2019). doi: 10.1038/s41598-019-48914-7

Mosser et al Fig 4

 

Inherited and de novo genetic risk for autism impacts shared networks
Elizabeth K. Ruzzo, Laura Pérez-Cano, Jae-Yoon Jung, Lee-Kai Wang, Dorna Kashef-Haghighi, Chris Hartl, Chanpreet Singh, Jin Xu, Jackson N. Hoekstra, Olivia Leventhal, Virpi M. Leppä, Michael J. Gandal, Kelley Paskov, Nate Stockham, Damon Polioudakis, Jennifer K. Lowe, David A. Prober, Daniel H. Geschwind and Dennis P. Wall
Cell 178, 850-866 (2019). doi: 10.1016/j.cell.2019.07.015

 Ruzzo zebrafish figure

 

The serotonergic raphe promote sleep in zebrafish and mice
Grigorios Oikonomou, Michael Altermatt, Rong-wei Zhang, Gerard M. Coughlin, Christin Montz, Viviana Gradinaru and David A. Prober
Neuron 103 (2019). doi: 10.1016/j.neuron.2019.05.038
Caltech press release | Neuron video abstract

tph2 5ht IHC data

 

Muller glial cells participate in retinal waves via glutamate transporters and AMPA receptors
Rong-wei Zhang, Wen-jie Du, David A. Prober and Jiu-lin Du
Cell Reports 27, 2871-2880 (2019). doi: 10.1016/j.celrep.2019.05.011

The neuromodulator adenosine regulates oligodendrocyte migration at motor exit point transition zones
Laura Fontenas, Taylor G. Welsh, Melanie Piller, Patricia Coughenour, Avni V. Gandhi, David A. Prober and Sarah Kucenas
Cell Reports 27, 115-128 (2019). doi: 10.1016/j.celrep.2019.03.013

Linking immunity and sickness-induced sleep
Grigorios Oikonomou and David A. Prober
Science 363, 455-456 (2019). doi: 10.1126/science.aaw2113
Reprint


2018

Discovery of hypocretin/orexin ushers in a new era of sleep research
David A. Prober
Trends in Neuroscience 41, 70-72 (2018). doi: 10.1016/j.tins.2017.11.007.

Hypocretin underlies the evolution of sleep loss in the Mexican cavefish
James B. Jaggard, Bethany A. Stahl, Evan Lloyd, David A. Prober, Eric R. Duboue and Alex C. Keene
Elife 7 (2018). doi: 10.7554/eLife.32637.
The Scientist | Nature


2017

Neuropeptide Y regulates sleep by modulating noradrenergic signaling
Chanpreet Singh, Jason Rihel and David A. Prober
Current Biology 27, 3796-3811 (2017). doi: 10.1016/j.cub.2017.11.018.
Caltech press release

 NPY FISH

 

Genetic and neuronal regulation of sleep by neuropeptide VF
Daniel A. Lee, Andrey Andreev, Thai V. Truong, Audrey Chen, Andrew J. Hill, Grigorios Oikonomou, Uyen Pham, Young K. Hong, Steven Tran, Laura Glass, Viveca Sapin, Jae Engle, Scott E. Fraser and David A. Prober
Elife 6 (2017). doi: 10.7554/eLife.25727.
Caltech press release

npvf projections

 

The Jellyfish Cassiopea exhibits a sleep-like state
Ravid D. Nath, Claire N. Bedbrook, Michael J. Abrams, Ty Basinger, Justin S. Bois, David A. Prober, Paul W. Sternberg, Viviana Gradinaru and Lea Goentoro
Current Biology 27, 2984-2990 (2017). doi: 10.1016/j.cub.2017.08.024
Caltech press release | Caltech video | Current Biology DispatchNature | Science | New York Times | Washington Post | Newsweek

Jellyfish large

 

Light-dependent regulation of sleep and wake states by prokineticin 2 in zebrafish
Shijia Chen, Sabine Reichert, Chanpreet Singh, Grigorios Oikonomou, Jason Rihel and David A. Prober
Neuron 95, 153-168 (2017). doi: 10.1016/j.neuron.2017.06.001
Caltech press release

 Prok2 image for website publications.jpg

Attacking sleep from a new angle: contributions from zebrafish
Grigorios Oikonomou and David A. Prober
Current Opinion in Neurobiology 44, 80-88 (2017). doi: 10.1016/j.conb.2017.03.009
Oikonomou model.png

 

Genetic analysis of histamine signaling in larval zebrafish sleep
Audrey Chen, Chanpreet Singh, Grigorios Oikonomou and David A. Prober
eNeuro 4(1) (2017). doi: 10.1523/ENEURO.0286-16.2017

 histamine fig final.jpg

2016

Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway
Paula Suarez-Bregua, Eva Torres-Nunez, Ankur Saxena, Pedro Guerreiro, Ingo Braasch, David A. Prober, Paloma Moran, Jose Miguel Cerda-Reverter, Shao Jun Du, Fatima Adrio, Deborah M. Power, Adelino V.M. Canario, John H. Postlethwait, Marianne E. Bronner, Cristian Canestro and Josep Rotllant
FASEB Journal 31, 569-583 (2016). doi: 10.1096/fj.201600815R

hcrt pthl.jpg

 

Mapping a multiplexed zoo of mRNA expression
Harry M.T. Choi, Colby R. Calvert, Naeem Husain, David Huss, Julius C. Barsi, Benjamin E. Deverman, Ryan C. Hunter, Mihoko Kato, S. Melanie Lee, Anna C.T. Abelin, Adam Z. Rosenthal, Omar S. Akbari, Yuwei Li, Bruce A. Hay, Paul W. Sternberg, Paul H. Patterson, Eric H. Davidson, Sarkis K. Mazmanian, David A. Prober, Mat van de Rijn, Jared R. Leadbetter, Dianne K. Newman, Carol Readhead, Marianne E. Bronner, Barbara Wold, Rusty Lansford, Tatjana Sauka-Spengler, Scott E. Fraser and Niles A. Pierce
Development 143, 3632-3637 (2016). doi: 10.1242/dev.14037

Choi 2016 Figure 2.jpg


Morphological and physiological interactions between GnRH3 and hypocretin/orexin neuronal systems in zebrafish (Danio rerio)

Yali Zhao, Chanpreet Singh, David A. Prober and Nancy L. Wayne
Endocrinology 157, 4012-4020 (2016). doi: 10.1210/en.2016-1381

GnRH figure.jpg

 

A zebrafish genetic screen identifies neuromedin U as a regulator of sleep/wake states
Cindy N. Chiu*, Jason Rihel*, Daniel A. Lee, Chanpreet Singh, Eric A. Mosser, Shijia Chen, Viveca Sapin, Uyen Pham, Jae Engle, Brett J. Niles, Christin J. Montz, Sridhara Chakravarthy, Steven Zimmerman, Kourosh Salehi-Ashtiani, Marc Vidal, Alexander F. Schier and David A. Prober
Neuron 89, 842-856 (2016). doi: 10.1016/j.neuron.2016.01.007. * equal contribution
Caltech press release | Neuron press release | Neuron video abstract

Nmu model.png

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 BBC World Service play icon.png

 

 

QRFP and its receptors regulate locomotor activity and sleep in zebrafish
Audrey Chen*, Cindy N. Chiu*, Eric A. Mosser, Sohini Khan, Rory Spence and David A. Prober
Journal of Neuroscience 36, 1823-1840 (2016). doi: 10.1523/jneurosci.2579-15.2016. * equal contribution
Editor highlight | Cover video | Neuronline Summary

Chen-et-al-QRFP-JNeurosci-Cover.jpg

 

TRP channel mediated neuronal activation and ablation in freely behaving zebrafish
Shijia Chen*, Cindy N. Chiu*, Kimberley L. McArthur, Joseph R. Fetcho and David A. Prober
Nature Methods 13, 147-150 (2016). doi: 10.1038/nmeth.3691. * equal contribution

  

  

2015

Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish
Chanpreet Singh*, Grigorios Oikonomou* and David A. Prober
Elife 4 (2015). doi: 10.7554/eLife.07000. * equal contribution

 Singh-Hcrt-LC-MO-projections.jpg

 

Melatonin is required for the circadian regulation of sleep
Avni V. Gandhi, Eric A. Mosser, Grigorios Oikonomou and David A. Prober
Neuron 85, 1193-1199 (2015). doi: 10.1016/j.neuron.2015.02.016
Caltech press release | Caltech video

Gandhi pineal images.jpg 

 

Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9
Justin Liu, Florian T. Merkle, Avni V. Gandhi, James A. Gagnon, Ian G. Woods, Cindy N. Chiu, Tomomi Shimogori, Alexander F. Schier and David A. Prober
Development 142, 1113-1124 (2015). doi: 10.1242/dev.117424

 Liu images.jpg

 

 2013

Regulation of zebrafish sleep and arousal states: current and prospective approaches
Cindy N. Chiu and David A. Prober
Frontiers in Neural Circuits 7:58 (2013). doi: 10.3389/fncir.2013.00058

Chiu-and-Prober-2013-neuroanatomy.jpg

 

A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly
Shijia Chen*, Grigorios Oikonomou*, Cindy N. Chiu, Brett J. Niles, Justin Liu, Daniel A. Lee, Igor Antoshechkin and David A. Prober
Nucleic Acids Research 41, 2769-2778 (2013). doi: 10.1093/nar/gks1356. * equal contribution

Chen-et-al-NAR-2013-ZFN-TALEN.jpg 

 

2010

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
Jason Rihel*, David A. Prober*, Anthony Arvanites, Kelvin Lam, Steven Zimmerman, Sumin Jang, Stephen J. Haggarty, David Kokel, Lee L. Rubin, Randall T. Peterson and Alexander F. Schier
Science 327, 348-351 (2010). doi: 10.1126/science.1183090. * equal contribution
Harvard Gazette | MIT Tech Review

 Rihel clustergram.png

 

Monitoring neural activity with bioluminescence during natural behavior
Eva A Naumann*, Adam R. Kampff *, David A Prober, Alexander F. Schier and Florian Engert
Nature Neuroscience 13, 513-520 (2010). doi: 10.1038/nn.2518. * equal contribution

Hypocretin-Aequorin.jpg

 

Monitoring sleep and arousal in zebrafish
Jason Rihel, David A. Prober and Alexander F. Schier
Methods in Cell Biology 100, 281-294 (2010). doi: 10.1016/B978-0-12-384892-5.00011-6

Rihel methods 2010.png 

 

2008

Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function
David A. Prober, Steven Zimmerman, Benjamin R. Myers, Brian M. McDermott Jr, Seok-Hyung Kim, Sophie Caron, Jason Rihel, Lilianna Solnica-Krezel, David Julius, A.J. Hudspeth and Alexander F. Schier
Journal of Neuroscience 28, 10102-10110 (2008). doi: 10.1523/jneurosci.2740-08.2008

Prober TRPA1.png 

 

2006

Hypocretin/Orexin overexpression induces an insomnia-like phenotype in zebrafish
David A. Prober, Jason Rihel, Anthony A. Onah, Rou-Jia Sung and Alexander F. Schier
Journal of Neuroscience 25(51):134000-13410 (2006).
Editor highlight

 Prober 2006.png 


Earlier publications

Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
David A. Prober and Bruce A. Edgar
Genes and Development 16, 2286-2299 (2002)

Growth regulation by oncogenes - new insights from model organisms
David A. Prober and Bruce A. Edgar
Current Opinion in Genetics and Development 11, 19-26 (2001)

Ras1 promotes cellular growth in the Drosophila wing
David A. Prober and Bruce A. Edgar
Cell 100, 435-446 (2000)

Drosophila myc regulates cellular growth during development
Laura A. Johnston, David A. Prober, Bruce A. Edgar, Robert N. Eisenman and Peter Gallant
Cell 98, 779-790 (1999)

pp60(c-src) is required for cell locomotion regulated by the hyaluronan receptor RHAMM
Christine L. Hall, Laurie A. Lange, David A. Prober, Shiwen Zhang and Eva A. Turley
Oncogene 13, 2213-2224 (1996)